Presented by The Sanford Consortium for Regenerative Medicine

The 4th Annual Stem Cell Meeting on the Mesa was an exclusive, one-day symposium which drew together the pioneers responsible for advancing research towards discovering cures for debilitating diseases and injuries. This one-day event featured renowned researchers...

The Harvard Stem Cell Institute marked its fifth anniversary in 2009. These conversations took place during the HSCI Stem Cell Symposium at the Harvard Club on November 6, 2009.

• Ethics,
• Regulation,
• Stem Cells

The Days of Molecular Medicine Forum, hosted by Roger Bingham, focuses on “Regulatory and Ethical Issues on the Use of Stem Cells: An...

• Biology,
• Ethics,
• Stem Cells

Welcome and introduction to the Basic Science panel

• Germ Line,
• Human Embryonic Stem Cells,
• Richard Scofield,
• Stem Cell Niche Hypothesis,
• Stem Cells

The Role of the Stem Cell Microenvironment in Regulating Stem Cell Behavior.

• Cardiac Differentiation,
• Embryology,
• Embryonic Stem Cells,
• Gene Expression,
• Heart Development,
• Human Embryonic Stem Cells,
• Stem Cell Differentiation,
• Stem Cells

Embryology-Based Strategies for Cardiac Differentiation of ES Cells

• Regeneration,
• Stem Cells,
• Vertebrate Regeneration

Deconstructing Vertebrate Regeneration

• Cancer,
• Cancer Stem Cells,
• Evolution,
• Leading Cause of Death,
• Oncology,
• Stem Cells

Cancer Stem Cell Research: From Bench to Bedside and Back

• Human Embryonic Stem Cells,
• Human Stem Cell Core Facility,
• Stem Cells,
• Technologies Panel,
• UCSD

Technologies Panel. UCSD Human Stem Cell Core Facility

• Human Embryonic Stem Cells,
• Modulation,
• Neurogenesis,
• Neurology,
• Osteoblasts,
• Regeneration,
• Stem Cells

Chemical and Functional Genomic Approaches Toward Regeneration

• Human Embryonic Stem Cells,
• Neurology,
• Stem Cells

Development of Functional Human Embryonic Stem Cell-Derived Neurons in Mouse Brain

• Differentiation,
• Human Embryonic Stem Cells,
• Markers,
• Morphology,
• Stem Cells,
• Transplants

Morphology of Undifferentiated hESCs in Culture

• Burnham Institute,
• Differentiation,
• Human Embryonic Stem Cells,
• Interaction,
• Migration,
• Stem Cells

Embryoid Body Cell Migration/Interaction Models: Toward Automatic Cell-by-Cell Tracking

• Burnham Institute,
• CIRM,
• Investment,
• Proposition 71,
• San Diego,
• Stem Cells

Moderator: Roger Bingham
State Senator Christine Kehoe
Zach Hall, CIRM
Robert Klein, CIRM
John Moores, JMI

• Egg Donation,
• Ethical Issues,
• Ethics,
• Human Embryonic Stem Cells,
• In Vitro Fertilization,
• Stem Cells

Clinical and Ethical Perspectives

• Association for Reproductive Medicine,
• Human Subjects,
• Informed Consent,
• Institutional Review Boards,
• Perspectives,
• Regulation,
• Stem Cells

Clinical and Ethical Perspectives

• Egg Donation,
• Human Embryonic Stem Cells,
• In Vitro Fertilization,
• Parents,
• Stem Cells

IVF in Intended Parents and Egg Donors: What Does This Mean?

• Cancer,
• Stem Cells

Technologies

• Nervous System,
• Receptor,
• Stem Cells,
• Technology

Technologies

• Neural Differentiation,
• Neural Induction,
• Retinoic Acid,
• Stem Cells

This is Your Brain on Politics

• Bioethics,
• Communication,
• Engaging the Public,
• Global Warming,
• Science Communication,
• Stem Cells,
• politics,
• science literacy

Sheril Kirshenbaum is co-author of Unscientific America: How Scientific Illiteracy Threatens Our Future with Chris Mooney describing...

Harvard Stem Cell Institute

• Cardiovascular Regenerative Medicine,
• Heart Transplant,
• Stem Cells

Humans as Model Organisms - Regenerative Mesa Medicine: Human, Human and Human

UC San Diego

• Cardiovascular Regenerative Medicine,
• Stem Cells

Introduction to the Cardiovascular Session

UC San Diego

• Cardiovascular Regenerative Medicine,
• Epicardial Progenitors,
• Epigenetics,
• Stem Cells

Epicardial Progenitors: Cells for Cardiac Repair/Regeneration?

Stanford University

• Cardiac Imaging,
• Cardiovascular Regenerative Medicine,
• Stem Cells

Clinical hurdles in stem cell therapy for heart disease: the role of cardiac imaging

Roger Bingham, Anthony DeMaria, Kenneth Chien

• Cardiovascular Regenerative Medicine,
• Patient Registries,
• Phenotyping,
• Stem Cells

Burnham Institute for Regenerative Medicine

• Cardiomyocytes,
• Cardiovascular Regenerative Medicine,
• Human Biology,
• Stem Cells

The chemical biology of stem cell cardiogenesis

The Scripps Research Institute

• Brain,
• Neurodegenerative Disorders,
• Stem Cells

Introduction to Neurodegenerative Session

UC San Diego

• Alzheimer's,
• Brain,
• Neurodegenerative Disorders,
• Stem Cells

Alzheimer's Disease

The Scripps Research Institute

• Neurodegenerative Disorders,
• Olfactory System,
• Stem Cells

Generating cell lines from post-mitotic neurons

UCLA

• Embryonic Stem Cells,
• Neurodegenerative Disorders,
• Stem Cells

Building novel neurological disease models using human ES cell-derived neurons

Floyd Bloom, Larry Goldstein, Kristin Baldwin, Yi Sun

• Neurodegenerative Disorders,
• Stem Cells

California Institute for Regenerative Medicine

• CIRM,
• Cancer,
• Stem Cells,
• Transcription Factors

Special Address by the CEO of the California Institute for Regenerative Medicine

Burnham Institute for Regenerative Medicine

• Diabetes,
• Glucose,
• Insulin,
• Obesity,
• Pancreas,
• Stem Cells

Introduction to Diabetes Session

University of Cincinnati

• Diabetes,
• Pancreas,
• Stem Cells,
• Translational Embryology

Translational embryology and Diabetes

UCLA

• Beta Cells,
• Diabetes,
• Embryogenesis,
• Stem Cell Differentiation,
• Stem Cells

Beta cell replication in adults

Novocell, Inc.

• Beta Cells,
• Cell Therapy,
• Diabetes,
• Human Embryonic Stem Cells,
• Insulin,
• Stem Cells

Engineering hESC to Create a Cell Therapy to Treat Insulin Requiring Diabetics

Fred Levine, Jason Wells, Anil Bhushan, Anne Bang

• Diabetes,
• Human Embryonic Stem Cells,
• Stem Cells

Salk Institute for Biological Studies

• Cancer,
• Stem Cells

Introduction to Cancer Session

UC San Diego

• Achilles,
• Cancer,
• Leukemia,
• Molecular Evolution,
• Oncology,
• Stem Cells

The Molecular Evolution of Leukemic Stem Cells

UCLA

• Cancer,
• Hematopoietic Stem Cells,
• Leukemia,
• Oncology,
• Stem Cells

Defining and recreating the niche for hematopoietic stem cell self-renewal

Salk Institute for Biological Studies

• Cancer,
• Glioblastoma,
• Oncology,
• Stem Cells,
• genetics

Glioblastoma: The terminator

Inder Verma, Catriona Jamieson, Hanna Mikkola

• Cancer,
• Oncology,
• Stem Cells

Alan Trounson, Neil Gibson, Stephen Laderman, Catriona Jamieson, Joydeep Goswami

• Cancer,
• Diabetes,
• Industry,
• Invitrogen,
• Pfiser,
• Stem Cells

Roger Bingham, Mary Anne Fox, Joydeep Goswami

• Proposition 71,
• Salk Institute,
• Stem Cells,
• UCSD

Evan Snyder

• Chromatin,
• DNA,
• DNA Structure,
• Differentiation,
• Epigenetics,
• Gene Expression,
• Methylation,
• Stem Cells,
• Transcription

Joel Gottesfeld

• Disease,
• Epigenetics,
• Friedreich's Ataxia,
• Neurodegenerative Disorders,
• Stem Cells,
• Therapeutical Applications of Stem Cells,
• Transcription

Siavash Kurdistani

• Cancer,
• Cancer Development,
• Chromatin,
• DNA,
• Differentiation,
• Epigenetics,
• Linker Histones,
• Stem Cells

Ryan Lister

• DNA,
• DNA Methylation,
• Differentiation,
• Epigenetics,
• Hematopoeietic Stem Cells,
• San Diego Epigenome Center,
• Sequencing,
• Stem Cells,
• genome,
• mC

Kristin Baldwin

• Fibroblasts,
• RNA,
• Reprogramming,
• Somatic Cell Nuclear Transfer,
• Stem Cells,
• Totipotency,
• iPS

Richard Gregory

• Embryonic Stem Cells,
• Proliferation,
• RNA,
• Stem Cell Mechanisms,
• Stem Cells,
• Translation,
• microRNA biogenesis

Jeanne Loring

• DNA,
• DNA Methylation,
• Microarray,
• Multipotent,
• Pluripotent,
• RNA,
• Stem Cells,
• Subcellular Systems Biology,
• biomarkers

Floyd Bloom, Kristin Baldwin, Richard Gregory and Jeanne Loring

• Cell Types,
• DNA Methylation,
• Differentiation,
• Human Stem Cells,
• Methylation,
• RNA,
• Stem Cells,
• mRNA,
• microRNA

David Brenner

• CIRM,
• Degenerative Disease,
• Future of Stem Cell Research,
• Regenerative Medicine,
• Sanford Consortium for Regenerative Medicine,
• Stem Cells

Catriona Jamieson

• Cancer,
• Cancer Stem Cells,
• Clinical Trials,
• MON,
• Myeloproliferative Neoplasm,
• Progenitor Cells,
• Proliferation,
• Stem Cells

Wendy Levin

• Breast Cancer,
• Cancer,
• Cancer Stem Cells,
• Hedgehog Pathway,
• Leukemia,
• Phenotype,
• Radiation,
• Stem Cells,
• Tumors

John Reed

• Chemical Library Screening,
• ESC Screen,
• Embryonic Stem Cells,
• Manipulating Stem Cells,
• Regenerative Medicine,
• Stem Cells,
• iPS Cells

Patricia Churchland

• Abortion,
• Church,
• Ethics,
• God's Intent,
• History of Science,
• Medical Technology,
• Opposition,
• Public Response to Science,
• Smallpox,
• Stem Cells,
• religion

Catriona Jamieson, Wendy Levin, John Reed and Patricia Churchland

• Francis Bacon,
• Opposition,
• Religion and Science,
• Science Communication,
• Scientific Advances,
• Scientific Hypotheses,
• Stem Cells,
• religion,
• science literacy

Alan Trounson

• CIRM,
• Genetic Engineering,
• ICAC,
• Retroviral Induction,
• Somatic Cell Nuclear Transfer,
• Stability,
• Stem Cells,
• Transduction,
• iPS Cells

Lawrence Goldstein

• Alzheimer's Disease,
• Amyloid Plaques,
• Disease Model,
• Fibroblasts,
• Neurons,
• Stem Cells,
• fad iPS Cells,
• iPS Cells

Roel Nusse

• Epiblast Stem Cells,
• Gene Expression,
• Self Renewal,
• Stem Cells,
• Target Genes,
• Wnt Pathway,
• genetics,
• iPS Cells

Alan Trounson, Kristen Brennand, Lawrence Goldstein and Roel Nusse

• Degenerative Disease,
• Diagnostics,
• Disease Prediction,
• Gene Expression,
• Phenotype,
• Stem Cells,
• Therapeutic Application of Stem Cells,
• iPS Cells

Stephen Laderman and Roger Bingham

• Agilent,
• DNA,
• Stem Cells

A Conversation with Amy Wagers

• Aging,
• Disease,
• Regenerative Medicine,
• Stem Cells,
• iPS Cells,
• metabolism

Amy Wagers is Principal Investigator in the section on Developmental and Stem Cell Biology at Joslin Diabetes Center and Assistant Professor in...

A conversation with Kenneth Chien

• Ethics,
• Immunology,
• Regenerative Medicine,
• Stem Cells,
• Transplantation,
• iPS Cells

Kenneth Chien is the Director of the Cardiovascular Research Center at Massachusetts General Hospital, and Professor in the Department of Cell...

A Conversation with Doug Melton

• Mechanism,
• Stem Cells,
• Treatment,
• Type 1 Diabetes,
• iPS Cells

Doug Melton is the Thomas Dudley Cabot Professor in the Department of Natural Sciences at Harvard University and an Investigator of the Howard...

A conversation with George Daley

• CIRM,
• Disease,
• Ethics,
• Reprogramming,
• Stem Cells,
• iPS Stem Cells

George Daley is Samuel E Lux, IV Chair in the Department of Hematology, Associate Professor of Biological Chemistry, Molecular Pharmacology and of...

Harvard Stem Cell Institute Panel

• Diabetes,
• Regenerative Medicine,
• Stem Cells,
• Treatment,
• iPS Cells

This panel was made up of  Kenneth Zaret, Douglas Melton, E. Edward Baetge,...

Changing life as we know it

• Aging,
• Awards,
• Biology,
• Disease,
• Economy,
• Global Health,
• Public Policy,
• Robotics,
• Science in Media,
• Social Interaction,
• Stem Cells,
• Technology,
• Women,
• language,
• science

A discussion about the consequences of prolonging life and the enhanced human brain/ computer interface.

Newcastle University

• Aging,
• Damaged Cells,
• Death,
• Life expectancy,
• Maintenance,
• Mechanisms,
• Medical Advances,
• Mortality,
• Nature,
• Repair,
• Stem Cells,
• Systems Biology,
• genetics

Tom Kirkwood is the Director of the Institute for Ageing and Health at Newcastle University. His research is focused on evolution and genetics of...

Sleep Aging

• Aging,
• Calorie Restriction,
• Drosophila,
• Functional Senescence,
• Immune system,
• Life span,
• Restoration,
• Stem Cells,
• sleep

Paul Shaw is Assistant Professor in the Department of Anatomy and Neurobiology at Washington University in St. Louis, Missouri. His research is...

• Aging,
• Caloric restriction,
• Diet,
• Drosophila,
• Obesity,
• Stem Cells,
• TOR,
• Technology,
• sleep

Marc Tatar is a Professor of Biology at Brown University. His research is focused on understanding the genetics, mechanisms and the evolution of...

• Aging,
• Biochemistry,
• C. Elegans,
• Caloric restriction,
• Central Nervous System,
• Development,
• Fasting,
• Stem Cells

Shilpi Khare is a Ph.D. student in the lab of Steven Clarke. She is studying the effects of oxidative stress of protein- repair deficient worms...